Daniel Sutherlin : rechercher sur Z-Library

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Articles (32)
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Structure-based design of thienobenzoxepin inhibitors of PI3-kinase

Steven T. Staben, Michael Siu, Richard Goldsmith, Alan G. Olivero, Steven Do, Daniel J. Burdick, Timothy P. Heffron, Jenna Dotson, Daniel P. Sutherlin, Bing-Yan Zhu, Vickie Tsui, Hoa Le, Leslie Lee, J

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2011

Synthesis of tetrasubstituted thiophenes on solid-support using the Gewald reaction

Georgette M Castanedo, Daniel P Sutherlin

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 107 KB

english, 2001

Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer

Sutherlin, Daniel P., Sampath, Deepak, Berry, Megan, Castanedo, Georgette, Chang, Zhigang, Chuckowree, Irina, Dotson, Jenna, Folkes, Adrian, Friedman, Lori, Goldsmith, Richard, Heffron, Tim, Lee, Lesl

Journal:

Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 3.35 MB

english, 2010

Additional Observations on Blood Parasites of Birds in Costa Rica

Valkiūnas, Gediminas, Iezhova, Tatjana A., Brooks, Daniel R., Hanelt, Ben, Brant, Sara V., Sutherlin, Marie E., Causey, Douglas

Journal:

Journal of Wildlife Diseases

Année:

2004

Langue:

english

Fichier:

PDF, 84 KB

english, 2004

Kilogram-Scale Asymmetric Ruthenium-Catalyzed Hydrogenation of a Tetrasubstituted Fluoroenamide

Andreas Stumpf, Mark Reynolds, Daniel Sutherlin, Srinivasan Babu, Erhard Bappert, Felix Spindler, Michael Welch, John Gaudino

Journal:

Advanced Synthesis & Catalysis

Année:

2011

Langue:

english

Fichier:

PDF, 217 KB

english, 2011

ChemInform Abstract: Combinatorial Chemistry in Steroid Receptor Drug Discovery.

John A. Flygare, Daniel P. Sutherlin, S. David Brown

Journal:

ChemInform

Année:

2002

Fichier:

PDF, 24 KB

2002

Strategies for the Synthesis of C-disaccharides containing D and L sugars

Robert W. Armstrong, Daniel P. Sutherlin

Journal:

Tetrahedron Letters

Année:

1994

Langue:

english

Fichier:

PDF, 183 KB

english, 1994

CDK2/cyclinA inhibitors: Targeting the cyclinA recruitment site with small molecules derived from peptide leads

Georgette Castanedo, Kevin Clark, Shumei Wang, Vickie Tsui, Mengling Wong, John Nicholas, Dineli Wickramasinghe, James C. Marsters Jr., Daniel Sutherlin

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 253 KB

english, 2006

Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase

Steven T. Staben, Timothy P. Heffron, Daniel P. Sutherlin, Seema R. Bhat, Georgette M. Castanedo, Irina S. Chuckowree, Jenna Dotson, Adrian J. Folkes, Lori S. Friedman, Leslie Lee, John Lesnick, Crist

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1007 KB

english, 2010

Stereoselective synthesis of dipyranyl C-disaccharides

Daniel P. Sutherlin, Robert W. Amrstrong

Journal:

Tetrahedron Letters

Année:

1993

Langue:

english

Fichier:

PDF, 208 KB

english, 1993

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors

Young-Tae Chang, Nathanael S Gray, Gustavo R Rosania, Daniel P Sutherlin, Soojin Kwon, Thea C Norman, Radhika Sarohia, Maryse Leost, Laurent Meijer, Peter G Schultz

Journal:

Chemistry & Biology

Année:

1999

Langue:

english

Fichier:

PDF, 4.36 MB

english, 1999

10.1038/73753

Schultz, Peter G., Rosania, Gustavo R., Chang, Young-Tae, Perez, Omar, Sutherlin, Daniel, Dong, Helin, Lockhart, David J.

Journal:

Nature Biotechnology

Année:

2000

Langue:

english

Fichier:

PDF, 262 KB

english, 2000

A Substrate-Phage Approach for Investigating Caspase Specificity

Samantha Lien, Richard Pastor, Daniel Sutherlin, Henry B. Lowman

Journal:

The Protein Journal

Année:

2004

Langue:

english

Fichier:

PDF, 203 KB

english, 2004

Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf

Daniel P. Sutherlin, Stewart Baker, Angelina Bisconte, Paul M. Blaney, Anthony Brown, Bryan K. Chan, David Chantry, Georgette Castanedo, Paul DePledge, Paul Goldsmith, David M. Goldstein, Timothy Hanc

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2012

A Unified Model for Apical Caspase Activation

Kelly M Boatright, Martin Renatus, Fiona L Scott, Sabina Sperandio, Hwain Shin, Irene M Pedersen, Jean-Ehrland Ricci, Wade A Edris, Daniel P Sutherlin, Douglas R Green, Guy S Salvesen

Journal:

Molecular Cell

Année:

2003

Langue:

english

Fichier:

PDF, 572 KB

english, 2003

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer

Sutherlin, Daniel P., Bao, Linda, Berry, Megan, Castanedo, Georgette, Chuckowree, Irina, Dotson, Jenna, Folks, Adrian, Friedman, Lori, Goldsmith, Richard, Gunzner, Janet, Heffron, Timothy, Lesnick, Jo

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 3.50 MB

english, 2011

Generation of C-Glycoside Peptide Ligands for Cell Surface Carbohydrate Receptors Using a Four-Component Condensation on Solid Support

Sutherlin, Daniel P., Stark, Todd M., Hughes, Robert, Armstrong, Robert W.

Journal:

Journal of Organic Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 146 KB

english, 1996

Pharmacokinetic drivers of toxicity for basic molecules: Strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor

Dolores Diaz, Kevin A. Ford, Dylan P. Hartley, Eric B. Harstad, Gary R. Cain, Kirsten Achilles-Poon, Trung Nguyen, Jing Peng, Zhong Zheng, Mark Merchant, Daniel P. Sutherlin, John J. Gaudino, Robert K

Journal:

Toxicology and Applied Pharmacology

Année:

2013

Langue:

english

Fichier:

PDF, 636 KB

english, 2013

Ceramic/polymer interpenetrating networks exhibiting increased ionic conductivity with temperature control of ion conduction for thermal runaway protection

Abudakka, Mohamed, Decker, Daniel S., Sutherlin, Logan T., Teeters, Dale

Journal:

International Journal of Hydrogen Energy

Année:

2014

Langue:

english

Fichier:

PDF, 744 KB

english, 2014

Synthesis of 12 Stereochemically and Structurally Diverse C-Trisaccharides

Sutherlin, Daniel P., Armstrong, Robert W.

Journal:

Journal of Organic Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 547 KB

english, 1997

Discovery and preclinical development of vismodegib

Gould, Stephen E, Low, Jennifer A, Marsters, James C, Robarge, Kirk, Rubin, Lee L, de Sauvage, Frederic J, Sutherlin, Daniel P, Wong, Harvey, Yauch, Robert L

Journal:

Expert Opinion on Drug Discovery

Année:

2014

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2014

A Method for Directed Evolution and Functional Cloning of Enzymes

Henrik Pedersen, Swen Holder, Daniel P. Sutherlin, Urs Schwitter, David S. King and Peter G. Schultz

Journal:

Proceedings of the National Academy of Sciences

Année:

1998

Langue:

english

Fichier:

PDF, 1.12 MB

english, 1998

The Synthesis of C-Trisaccharides Exploiting the Stereochemical Diversity of a Central Sugar

Sutherlin, Daniel P., Armstrong, Robert W.

Journal:

Journal of the American Chemical Society

Année:

1996

Langue:

english

Fichier:

PDF, 163 KB

english, 1996

Activation and Substrate Specificity of Caspase-14 †

Mikolajczyk, Jowita, Scott, Fiona L., Krajewski, Stan, Sutherlin, Daniel P., Salvesen, Guy S.

Journal:

Biochemistry

Année:

2004

Langue:

english

Fichier:

PDF, 202 KB

english, 2004

Selective α4β7 Integrin Antagonists and Their Potential as Antiinflammatory Agents

Dubree, Nathan J. P., Artis, Dean R., Castanedo, Georgette, Marsters, James, Sutherlin, Daniel, Caris, Lisa, Clark, Kevin, Keating, Susan M., Beresini, Maureen H., Chiu, Henry, Fong, Sherman, Lowman,

Journal:

Journal of Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 150 KB

english, 2002

Preclinical stereoselective disposition and toxicokinetics of two novel MET inhibitors

Liederer, Bianca M., Liu, Xingrong, Berezhkovskiy, Leonid M., Cain, Gary, Ding, Xiao, Gaudino, John, Kaus, Robert, Plise, Emile G., Sutherlin, Daniel P., Harstad, Eric B.

Journal:

Xenobiotica

Année:

2012

Langue:

english

Fichier:

PDF, 806 KB

english, 2012

Structural Basis of Nav1.7 Inhibition by an Isoform-Selective Small Molecule Antagonist

Hackos, David H., Ahuja, Shivani, Mukund, Susmith, Deng, Lunbin, Khakh, Kuldip, Chang, Elaine, Young, Clint, Lin, Sophia, Johnson, J.P., Ortwine, Daniel F., Safina, Brian S., Sutherlin, Daniel P., Coh

Journal:

Biophysical Journal

Année:

2016

Langue:

english

Fichier:

PDF, 66 KB

english, 2016

Investigation of Dose-Dependent Factors Limiting Oral Bioavailability: Case Study With the PI3K-δ Inhibitor

Chiang, Po-Chang, Sutherlin, Daniel, Pang, Jodie, Salphati, Laurent

Journal:

Journal of Pharmaceutical Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 825 KB

english, 2016

Activation of caspases-8 and -10 by FLIP L

BOATRIGHT, Kelly M., DEIS, Cristina, DENAULT, Jean-Bernard, SUTHERLIN, Daniel P., SALVESEN, Guy S.

Journal:

Biochemical Journal

Année:

2004

Langue:

english

Fichier:

PDF, 358 KB

english, 2004

Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors

Chernov-Rogan, Tania, Li, Tianbo, Lu, Gang, Verschoof, Henry, Khakh, Kuldip, Jones, Steven W., Beresini, Maureen H., Liu, Chang, Ortwine, Daniel F., McKerrall, Steven J., Hackos, David H., Sutherlin,

Journal:

Proceedings of the National Academy of Sciences

Année:

2018

Langue:

english

Fichier:

PDF, 1.37 MB

english, 2018

Na v 1.7 inhibitors for the treatment of chronic pain

McKerrall, Steven J., Sutherlin, Daniel P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2018

Langue:

english

Fichier:

PDF, 1.85 MB

english, 2018

[American Institute of Aeronautics and Astronautics 2018 Joint Propulsion Conference - Cincinnati, Ohio ()] 2018 Joint Propulsion Conference - Investigation into Cryogenic Tank Insulation Systems for the Mars Surface Environment

Johnson, Wesley L., Hauser, Daniel M., Banker, Brian, Sutherlin, Steven, Smith, James, Stephens, Jonathan, Plachta, David, Valenzuela, Juan, Desai, Pooja

Langue:

english

Fichier:

PDF, 811 KB

english